Monday, December 24, 2012

Feline Health Tips

Some helpful tips on the feline community


The incubation period of herpes is 2-6 days. Most cats that have recovered from herpes will be carriers of the virus for life. They shed it intermittently under normal conditions and during times of stress. This shedding can begin a week after the stressful incident and continue for 3 weeks afterward. They may shed virus after recovery from illness for 3 weeks.


The incubation period of calici virus is 1-5 days. Some cats that have recovered from infection will shed the virus continuously for the rest of their lives without regard to stress. 50% shed at least 75 days post-recovery regardless of stress. Fortunately most cats do eliminate calici virus from their bodies eventually.


It is believed that there is a carrier state with bordetella, but the mechanisms are not entirely clear yet. Bordetella has an incubation period of 3-10 days and can be shed for 3 months post recovery. Transmission is via direct contact, fomites and aerosol. It is zoonotic but human cases are believed to be rare.


The incubation period of chlamydophila is 3-14 days and post recovery shedding can last as long as 18 months. Transmission of the organism is either through direct contact or fomites. It is zoonotic.


This intracellular bacteria is commonly isolated from the oropharynx of normal cats. The role that Mycoplasma plays in feline URI has not been fully established. Mycoplasma is passed from cat to cat via direct transmission, with minimal transmission via fomites. It does not survive well in the environment and it is killed by routine disinfection. Routine disinfection and timely isolation of symptomatic cats is best to control this disease in the shelter.

Clinical Signs

Most cats with signs of upper respiratory disease suffer from bouts of sneezing and runny eyes. In most cases, shelters do not bother to distinguish between the different disease causing agents. However, it is important to make the distinction in order to design effective control measures, such as vaccination or treatment protocols.

Diagnostic testing should be undertaken under the following circumstances: when signs persist for over a month; signs are unusually severe or frequent; prior to treatment with steroids; and for liability issues.


The lethargy, sneezing, ocular and nasal discharges may be worse with herpes than the other diseases. Herpes is also accompanied by fever, depression, loss of appetite, eye ulcers and drooling.


Calici virus produces oral ulcers and lameness. These may be the only signs or they may be seen in combination with the same signs as herpes, only milder. There is a virulent systemic calici virus syndrome that causes sudden death in vaccinated adult cats as well as kittens and other animals that would ordinarily be considered protected. A description of the syndrome can be found at the website managed by the University of California Koret Shelter Medicine Program.


Chlamydophila produces a serious conjunctivitis (eye infection), accompanied by mild sneezing. This same organism may cause conjunctivitis in humans.


 Bordetella is still being researched. It is believed to cause fever, sneezing, nasal discharge, enlargement of the lymph nodes found under the throat and loud, harsh lung sounds. Coughing may also be observed.


This bacteria most commonly causes ocular signs including ocular discharge and swelling of the conjunctiva.


Diagnosis is generally made based on the clinical signs. Cultures from the mouth, throat, eyes or nose may be sent to the laboratory for confirmation. There are PCR diagnostic kits available from Idexx and Zoologix that provide a feline upper respiratory diagnostic panel.


Treatment for the viral diseases is symptomatic. Isolation is essential if cats with URI are to be treated in the shelter, but placing infected animals in foster care is a better management strategy. Good nursing care (wiping away ocular and nasal discharges, force-feeding, keeping warm, etc.) is essential for the comfort of these animals.

Broad-spectrum systemic antibiotics to protect against secondary bacterial infections may be necessary because of the increased risk of exposure in shelters, but they should generally be reserved for animals with purulent ocular and nasal discharges, anorexia, depression, dehydration, etc. Tetracycline, doxycycline or Clavamox are the drugs of choice to use against secondary bacterial invasions as well as against bordetella, chlamydophila and mycoplasma. Doxycycline is less likely than tetracycline to cause yellow staining of the teeth in younger animals. However, doxycycline can result in esophageal stricture, so it must be used with caution.

Ophthalmic ointment may be needed in some cases. The ophthalmic ointment should contain an antibiotic but NOT a steroid (as a cat may have a corneal ulcer which can be made worse by the use of a steroid ointment in the eye). Examples of ophthalmic ointments recommended include Terramycin, Chloramphenicol, and triple antibiotic ophthalmic ointment.

Fluid therapy may be necessary in severe cases. Antiviral drugs may be necessary in the form of eye drops for herpes viral-induced eye lesions. Cats who are unable to smell their food as a result of the infection may lose their appetite and refuse to eat, so they must be encouraged by offering foods with strong aromas, baby foods or other soft and blended foods. It may be necessary to place a nasogastric tube to force feed them if they continue to refuse to eat. L-lysine can also be used as a nutritional supplement to decrease the severity of symptoms of feline URI. Steam inhalation or nebulizers may also be helpful.

Shelters must consider carefully the resources they have available and the risk to healthy cats when undertaking treatment. A cat who needs only minimal treatment to recover from an upper respiratory infection may pass it on to another cat who requires intensive care therapy. Once the shelter has run out of space to isolate sick animals or place them in foster care, it may be necessary to consider euthanasia to protect the lives of the rest of the animals.

Management and Prevention


It is critical to disinfect the environment to control any disease outbreak even if the pathogen does not survive long term outside the host’s body. Except for calici virus, the respiratory pathogens are all fairly susceptible to chemical destruction:

•Herpes virus persists outside the animal's body for only about 18 hours and is easily destroyed by most disinfectants.

•Calici virus can persist for up to a week or longer in a damp environment and is slightly more resistant to disinfectants.

•Chlamydophila is unstable outside the host's body and can survive in ocular discharges at room temperature for several days.

• Mycoplasma does not survive well in the environment and is susceptible to routine disinfection.

Cleaning protocols for cats have changed dramatically over the past few years. Because it is well known that herpes virus reactivates with stress, any cleaning protocol must strive to minimize stress to cats. Studies have shown that the stress to cats that results from simply moving them from cage to cage can result in herpes reactivation.

New recommendations are to leave cats in their enclosures for the duration of their stay, and spot clean their cages, reserving disinfection for when a new animal is placed in the cage. Alternatively each cat can be assigned an adjoining cage and they can just move from one cage to the other while their cage is cleaned. The least desirable but still acceptable option is to assign each animal a carrier and place the cat in the same carrier each time she is removed from her cage while it is cleaned. No other cat may be placed in that carrier. For spot cleaning, the water bowls, food dishes, and litter boxes are removed from the cage and replaced with disinfected items. The cage is simply wiped down only in areas of visible soiling.

The entire cage is cleaned with soap and hot water, including the bars in the front, sides, bottoms and tops and disinfected whenever a new resident is introduced. The disinfectant should be applied and allowed contact with the surface according to the manufacturer's recommendations, and then rinsed. The cage should be completely dry before the cat is placed in it.

Sodium hypochlorite, or household bleach, is one of the most effective and inexpensive disinfectants available for shelters to use to kill calici virus as well as the other respiratory pathogens. If diluted 1:32 with warm water, it is less likely to be corrosive to the cage surfaces or act as an irritant to the cat's mucus membranes. Trifectant or potassium peroxymonosulfate is another excellent product to use for cleaning cat cages. It reliably kills parvo and calici virus, is easy to mix and use, and has the advantage of having some detergent properties and of being less irritating to mucus membranes and less corrosive to metal.

Staff, volunteers and the public should be instructed to avoid handling or touching animals during outbreaks especially. They should wash their hands thoroughly after each contact and wear protective garments.

Shelter Design

Cage placement and ventilation have a lot to do with the spread of disease. A cat's sneeze can travel about 3-4 feet, so it is important to have cat cages at least 4 feet apart if they are facing each other. Shelter traffic patterns should place as much distance as possible between sick wards and healthy ones. Staff who clean and work in several areas should start in the areas with healthy juvenile and susceptible animals and end in the areas with diseased animals.

Lack of adequate ventilation also plays a key part in disease spread. If an air exchange system is employed, there should be a minimum of 12-15 air changes per hour, preferably with outside air. If not, circulation patterns should go from healthy areas and kitten areas to sick areas. HEPA filters may be helpful in refreshing the air, but should not be relied on to counter inadequate ventilation systems. Avoid ozone and ion generators.

Fresh air is also extremely valuable in reducing incidence and severity of feline URI in shelters. Ideally, isolation areas as well as cat holding areas should have windows with screens that open to the outside, and these windows should be open when weather permits.

Disease Outbreak Management

The following other measures should help prevent and minimize the impact of upper respiratory infections:

•Examine all animals on intake.
•Isolate sick animals immediately.
•Vaccinate on intake all cats beginning at 4-6 weeks of age with a modified live vaccine for feline herpes (rhinotracheitis), calici and panleukopenia (FVRCP), with boosters every 2 weeks until 16-18 weeks of age.
•Adult cats may be given one injection, but a booster 2 weeks later should be considered in a high risk situation.
•Consider using an intranasal vaccine if URI is a real or persistent problem. Many shelters report excellent results in reducing the incidence of URI when switching vaccines from the parenteral (injectable) to intranasal product. Intranasal vaccines can be used in animals as young as 3 weeks of age if using the bivalent product against calici and herpes virus. The main advantage is that a faster immune response is seen compared to use of the injectable vaccine. The main drawbacks with the intranasal vaccines are that they are harder to administer and cause side effects that mimic actual clinical disease. The difference is that the animals with vaccine reactions still appear well and only sneeze and have runny eyes for a couple of days. Adopters of animals who have been given this vaccine should be advised of the side effects so they and their veterinarians will know what to expect. (If using an intranasal vaccine to prevent feline URI, a subcutaneous panleukopenia vaccine is still needed to prevent feline distemper. The panleukopenia vaccine is usually combined with calici and herpes virus, and this multivalent vaccine can be used in addition to an intranasal vaccine).
•Although there is still debate regarding whether or not bordetella is a primary cause of disease, some shelters report a decrease in the incidence of URI after using the intranasal bordetella vaccine. Positive cultures of bordetella should be obtained before using this product.
•Deworm kittens and cats routinely with a broad spectrum anthelmintic.
•Feed the best diet affordable, and for individual needs.
•Segregate kittens by litter and age groups. Kittens under 3 months of age are most susceptible to disease and should be separated from other litters and from adult animals, or placed in foster care until the outbreak is under control.
•Disinfect water bowls daily and between usages by different animals.
•Instruct staff, volunteers and visitors about spreading disease via fomites.
•Use hand sanitizers with 70% alcohol. Hand washing remains best.
•Post signs asking the public to prevent disease spread by washing their hands and to avoid handling animals without staff supervision.
•Use disposable litter pans, toys, cleaning cloths, food dishes, etc.
•Restrict the use of cleaning materials to individual rooms or wards.
•Launder uniforms in hot water, detergent and bleach.
•Reduce stress!
•Avoid crowding, loud noises.
•Consider colony housing in addition to conventional individual cages for some cats.
•Provide bedding, toys, perches and hiding places.
•Establish a routine for cleaning and other procedures.
•Maintain comfortable environmental conditions, evaluating temperature, humidity and ventilation in every animal holding area.
•Turn the lights off at night so animals can sleep.
•Provide access to natural light.
•Place mildly affected animals in foster homes where treatment can be continued without exposing all the animals to risk of infection.

 Credits: Lila Miller, DVM

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